Sunday, September 24, 2023

Difference Between Anti-Thrombotic and Anticoagulant Agent

  • Antithrombotic Agents

    • A group of drugs that include the following:
      • Antiplatelet drugs
      • Anticoagulants

  • Anticoagulant Agents

    • A variety of agents that inhibit one or more steps in the coagulation cascade
    • The following groups of drugs are included:
      • Unfractionated Heparin
      • Low molecular weight heparins
      • Fondaparinux
      • Vitamin K Antagonists
      • Direct FXa inhibotors
      • Indirect FXa inhibitor
      • Direct FIIa inhibitors
      • Indirect FIIa Inhibitors
      • Investigative Anticoagulants
        • FXIa inhibitors (Milvexian, Asundexian)
        • FXI inhibitors (Abelacimab)
        • Monoclonal Antibody for Active site of FXIa (Osocimab)
        • FXI synthesis inhibitor (Fesomersen)
        • FXIIa inhibitor (AB023)
        • Allosteric inhibitor of FXIa (Sulfated chiro-inositol)
        • TF/factor VIIa inhibitors (Recombinant TFPI and anti-TF antibodies, Nematode anticoagulant peptide-2)
        • Factor VIII inhibitor (TB-402)
        • Throombomodulin (ART-123)
        • Factor IXa inhibitor (REG1)
        • Factor XIIa inhibitor (Infestin-4)
        • Protein disulfide isomerase inhibitors (quercetins)
        • Polyphosphate inhibitors

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Domain Structure of Clotting Factor VIII (FVIII)

Synthesis as Peptide Chain   FVIII is synthesized as a single chain polypeptide of 2351 amino acids A 19-amino acid signal peptide is cleave...