Monday, September 25, 2023

Physiological Inhibitors of Coagulation System

There are many physiological inhibitors impacting various stages of coagulation system. Most important inhibitors with known physiology are enumerated as under: 

Antithrombin 
Protein C
Protein S 
Heparin
Heparin cofactor II
TFPI (Kunitz type inhibitor)
PZ & PZ dependent inhibitor 
𝛂1-Antitrypsin
𝛂2-Antiplasmin
α2-Macroglobulin
Protease Nexin 2 
C1-esterase inhibitor

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Domain Structure of Clotting Factor VIII (FVIII)

Synthesis as Peptide Chain   FVIII is synthesized as a single chain polypeptide of 2351 amino acids A 19-amino acid signal peptide is cleave...