Selection of APTT Reagent for Coagulation Lab

• Selection of Activated Partial Thromboplastin Test (APTT) reagent from a variety of available/offered reagents is very important. 
• Selected APTT reagent must be sensitive to: 
• Deficiency of FVIII → ≤35 – 40% (35 – 40 U/dL or 0.35 – 0.4 IU/mL) concentration of FVIII
• Deficiency of FIX → ≤35 – 40% (35 – 40 U/dL or 0.35 – 0.4 IU/mL) concentration of FIX
• Deficiency of FXI → ≤35 – 40% (35 – 40 U/dL or 0.35 – 0.4 IU/mL) concentration of FXI
• Unfractionated Heparin (UFH) over therapeutic range of 0.3 – 0.7 anti-Xa IU/mL
• Lupus anticoagulant (optional as per requirement of the lab setup)