- Polymorphisms in P450 CYP2C9*2 and CYP2C9*3 Hepatic Microsomal Enzyme System
- ↓ metabolism of warfarin
- ↓ warfarin dose requirements
- ↑ INR levels at a given dose
- ↑ risk for bleeding during warfarin therapy
- Duplication or Multiplication of Cyt P450 Enzyme Genes (P450 CYP2D6 & CYP2A6 )
- ↑ metabolic clearance of Warfarin
- Subtherapeutic INR
- Missense mutations of VKORC1 gene
- Warfarin resistance
- Polymorphisms in VKORC1 gene
- Inter-individual variability in the dose-anticoagulant effect of warfarin
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